Download 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr. PDF

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

ISBN-10: 1581106548

ISBN-13: 9781581106541

This bestselling and common source on pediatric antimicrobial remedy offers quick entry to trustworthy strategies for remedy of all infectious illnesses in children.

For every one sickness, the authors offer a statement to aid future health care services pick out the simplest of all antimicrobial offerings. The inquiring doctor can instantly hyperlink to the facts for the advice within the book or cellular model. Drug descriptions disguise all antimicrobial brokers to be had at the present time and contain whole information regarding dosing regimens.

In reaction to transforming into matters approximately overuse of antibiotics, the ebook contains instructions on while to not prescribe antimicrobials.

Key positive aspects in nineteenth Edition!

- up to date information about the energy and the extent of proof for all remedy options

- New bankruptcy on antibiotic treatment for overweight teenagers

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- comprises remedy of parasitic infections and tropical drugs.

- up-to-date anti-infective drug directory, entire with formulations and dosages.

- Balanced info on security, efficacy and tolerability with facts on expenses and availability of substances

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Extra resources for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Example text

Use of Antimicrobials During Pregnancy or Breastfeeding The use of antimicrobials during pregnancy should be balanced by the risk of fetal toxicity, including anatomical anomalies. A number of factors determine the degree of transfer of antibiotics across the placenta: lipid solubility, degree of ionization, molecular weight, protein binding, placental maturation, and placental and fetal blood flow. The FDA provides 5 categories to indicate the level of risk to the fetus: (1) Category A: fetal harm seems remote since controlled studies have not demonstrated a risk to the fetus; (2) Category B: animal reproduction studies have not shown a fetal risk but no controlled studies in pregnant women have been done, or animal studies have shown an adverse effect that has not been confirmed in human studies (penicillin, amoxicillin, ampicillin, cephalexin/cefazolin, azithromycin, clindamycin, vancomycin, zanamivir); (3) Category C: studies in animals have shown an adverse effect on the fetus but there are no studies in women and no animal data are available; the potential benefit of the drug may justify the possible risk to the fetus (chloramphenicol, ciprofloxacin, gentamicin, levofloxacin, oseltamivir, rifampin); (4) Category D: evidence exists of human fetal risk but the benefits may outweigh such risk (doxycycline); (5) Category X: The drug is contraindicated since animal or human studies have shown fetal abnormalities or fetal risk (ribavirin).

Insufficient data available to recommend valganciclovir extemporaneous suspension. Intravitreal ganciclovir and combination therapy for non-responding, immunocompromised hosts 46 — Chapter 6. Antimicrobial Therapy According to Clinical Syndromes C. EYE INFECTIONS (cont) D. 5 mg/kg/day IM (AIII) Other antipseudomonal antibiotics should also be effective: cefepime IV, meropenem IV or imipenem IV, pip/tazo – Bacterial furuncle of canal (S aureus, including CA-MRSA) Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (BIII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or vancomycin 40 mg/kg/day IV q8h (BIII) I&D; antibiotics for cellulitis Oral therapy for mild disease, convalescent therapy: for MSSA: cephalexin; for CA-MRSA: clindamycin, TMP/SMX, OR linezolid (BIII) – Candida Fluconazole 5–10 mg/kg/day PO qd for 5–7 days (CIII) May occur following antibiotic therapy of bacterial external otitis; debride canal Otitis media, acute A note on AOM: The natural history of AOM in different age groups by specific pathogens has not been well defined; therefore, the actual contribution of antibiotic therapy on resolution of disease has also been poorly defined until 2 recent, amoxicillin/clavulanate vs placebo, blinded, prospective studies were published (Hoberman A et al 201169 and Tähtinen P et al 201170) although neither study requested tympanocentesis to define a pathogen.

Critical evaluations of duration of therapy have been carried out in very few infectious diseases. In general, a longer duration of therapy should be used (1) for tissues in which antibiotic concentrations may be relatively low (eg, abscess, CNS infection) and tissues in which repair following infection-mediated damage is slow (eg, bone), (2) when the organisms are less susceptible, (3) when a relapse of infection is unacceptable (eg, CNS infections), or (4) when the host is immunocompromised in some way.

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