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Extra resources for Advances in lipid research. Vol.10
1966). It was proposed that the gelatin interacted with the lipid particle and, in essence, "coated" the surface of the lipid particle. By covering the lipophilic nature of the lipid particle with a protein coat, the particle now requires the presence of plasma humoral recognition factors for its phagocytosis. In all studies to date, the presence of heparin was essential for the expression of optimum phagocytosis (Filkins and Di Luzio, 1966b; Saba et al, 1966; Pisano and Di Luzio, 1970a). In studies on the properties of the recognition factor, it was found that the recognition factor essential for colloidal gold phagocytosis was destroyed by heating serum to 60°C.
Biochemistry 8, 3309. Schoefl, G. I. (1968). Proc. Boy. Soc. Ser. B 169, 147. Schoefl, G. , and French, J. E. ( 1968). Proc. Boy. Soc. Ser. B 169, 153. Schumaker, V. , and Adams, G. H. ( 1969). Annu. Bev. Biochem. 38, 113. , and Furman, R. H. (1969). /. Clin. Invest. 48, 1211. , Furman, R. , and McConathy, W. J. (1970). /. Clin. Invest. 49, 2396. , and Shore, V. (1969). Biochemistry 8, 4510. , and Stein, Y. ( 1967). /. Cell Biol 33, 319. Strauss, E. W. (1966). /. Lipid Res. 7, 307. Tillack, T. , and Marchesi, V.
Some particles (B and E) viewed from the top clearly show edges with fine serrations, while others (C and D ) , which represent tilted particles, appear to show a fine structure consisting of a strandlike network on the surface of the particle. One of the images (13D) shows a girdling structure around its equator. Pollard et al. (1969) obtained very different micrographs after using essentially the same negative staining technique. Electron microscopy of LDL by these authors resulted in the images shown in Fig.