Download Application of Short-Term Bioassays in the Fractionation and by Herbert S. Rosenkranz, Elena C. McCoy, Monica Anders, PDF

By Herbert S. Rosenkranz, Elena C. McCoy, Monica Anders, William T. Speck, David Bickers (auth.), Michael D. Waters, Stephen Nesnow, Joellen L. Huisingh, Shahbeg S. Sandhu, Larry Claxton (eds.)

ISBN-10: 1468436139

ISBN-13: 9781468436136

vi Williamsburg, Virginia, February 21-23, 1978. This symposium was once subsidized through the U. S. Environmental defense organization, place of work of strength Minerals and undefined, Washington, DC, and place of work of overall healthiness and Ecological results, health and wellbeing results Re­ seek Laboratory, Biochemistry department, learn Triangle Park, NC. The symposium consisted of 24 formal shows that magnify the 3 significant themes mentioned throughout the symposium: an summary of momentary bioassay structures; present method concerning the gathering and chemical research of environmental samples; and present examine in­ volving using non permanent bioassays within the fractionation and research of complicated environmental combos. the aim of this symposium was once to offer the state of the art tech­ niques in bioassay and chemical research as utilized to com­ plex combinations and to foster persisted development of this significant region. advanced combinations mentioned contain ambient air and water, waste water, consuming water, shale oil, syn­ thetic fuels, vehicle exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and foodstuff items. it's our desire that this quantity will function a refer­ ence to catalyze and inspire extra examine during this box. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment we wish to thank Gerald Rausa, place of work of strength Minerals and undefined, for his suggestion, encouragement, and aid of this software. we might additionally prefer to show our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa structures, Inc.

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Abstracts, 8th Ann Meeting, Amer Environ Mutagen Soc, pp 47-48, 1977 78. Rosenkranz HS: Aspects of microbiology in cancer research. Ann Rev Microbiol 27:383-401, 1973 79. Rosenkranz HS: MiracilD: Inhibition of deoxyribonucleic acid polymerase-deficient Escherichia coli. Antimicrob Ag Chemother 3:530-531, 1973 80. Rosenkranz HS: Hydroxylamine-a-sulfonic acid: In vitro and possible in vivo reaction with DNA. Chemico-Bi~ Interactions 7:195-204, 1973 81. Rosenkranz HS: Studies on the mutagenicity of nitrofurans in Salmonella typhimurium.

Furthermore, the reaction products of the hydrocarbons with the DNA of the V79 cells, after activation by the BHK cells, were indistinguishable from the products observed in vivo under conditions where tumorigenesis occurs. These findings further support the use of cell-mediated mutagenesis as a screen for carcinogenic sUbstances and indicate that basic mechanisms of carcinogenesis can be studied with this system. While fibroblas-tic cells are capable of metabolizing carcinogenic hydrocarbons to mutagenic intermediates, they are not capable of activating some other classes of chemical carcinogens, such as those which cause cancer of the liver.

Nature 264:624-627, 1976 77. Rao TK, Hardigree AA, Young JA, Epler JL: Correlation of mutagenic activity of energy related effluents with organic constituents. Abstracts, 8th Ann Meeting, Amer Environ Mutagen Soc, pp 47-48, 1977 78. Rosenkranz HS: Aspects of microbiology in cancer research. Ann Rev Microbiol 27:383-401, 1973 79. Rosenkranz HS: MiracilD: Inhibition of deoxyribonucleic acid polymerase-deficient Escherichia coli. Antimicrob Ag Chemother 3:530-531, 1973 80. Rosenkranz HS: Hydroxylamine-a-sulfonic acid: In vitro and possible in vivo reaction with DNA.

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