Download Arachidonic Acid in Cell Signaling by Daniele Piomelli PDF

By Daniele Piomelli

ISBN-10: 366205809X

ISBN-13: 9783662058091

This booklet is ready the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in sign transduction. Arachidonic acid may well function an intracellular moment messenger in lots of phone kinds, in addition to precursor for biologically energetic molecules reminiscent of the eicosanoids (a kin of oxygenated metabolites which may act as moment messengers or as neighborhood mediators), and anandamide (an endogenous cannabinoid substance). Dysfunctions within the arachidonic acid cascade underlie a couple of critical pathological stipulations, making those biochemical pathways the objective for medicinal drugs of medical value.

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Biochemistry 1986; 25:8381-8385. 35. Hayakawa M, Horigome K, Kudo I, Tomita M, Nojima S, Inoue K. Amino acid composition and NHrterminal amino acid sequence of rat platelet secretory phospholipase A2. J Biochem 1987; 101:1311-1314. 36. Kanda A, Ono T, Yoshida N, Tojo H, Okamoto M. The primary structure of a membrane-associated phospholipase A2 from human spleen. Biochem Biophys Res Comm 1989; 163:42-48. Pruzanski W, Vadas P, Plant S, Miller JA, Kloss J, 37. Seilhamer Johnson LK. Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid.

The enzymatic machinery necessary for the biosynthesis of the putative second messenger should be present in cells 2. Activating first messenger receptors should elicit the accumulation of the putative second messenger 3. A mechanism should exist for the rapid inactivation of the putative second messenger 4. Exogenous administration of the putative second messenger should mimic the biological response resulting from stimulating first messenger receptors 5. , cyclic AMP or inositoltrisphosphate, the cellular amounts of free arachidonate are finely tuned by a balance between receptor-dependent formation and enzymatic disposition.

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Nad Acad Sci USA 1992; 89:6147-6151. 72. Balsinde J, Barbour SE, Bianco I, Dennis EA. Arachidonic acid mobilization in P3881D J macro phages is controlled by two distinct phospholipase A2 enzymes. Proc Nad Acad Sci USA 1994; 91:11060-11064. 73. Pfeilschifter J, Schalwijk C, Brine VA, Van den Bosch H. Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. J Clin Invest 1993; 92:2516-2523.

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