By Parviz M. Pour M.D., Yoichi Konishi M.D. (auth.), Parviz M. Pour M.D., Yoichi Konishi M.D., Günter Klöppel M.D., Daniel S. Longnecker M.D. (eds.)
The type of tumors is critical for knowing tumor histogenesis, for predicting diagnosis, for differential analysis, and for recommending applicable remedy. considering 1836, while pancreatic melanoma was once first defined, development has been made in pancreatic melanoma morphology, and a few classifications were proposed. All of those classifications are frequently in accordance with morphological features. a few are too exact to be of sensible use whereas others are extra pragmatic. many of the inherent difficulties within the prior classifications integrated problems in acquiring an enough variety of pan creatic tumors for exam and inadequate medical facts and follow-up. With the expanding occurrence of pancreatic melanoma in lots of elements of the area in the past six a long time, and with the supply of extra tumors to patho logists, advances were made in pancreatic tumor reports. Classifications via Cubilla and Fitzgerald and by way of Kloppel, that are as a rule comparable, more often than not thought of fashionable morphological positive aspects and their histogenesis. those pathology-oriented classifications, even if whole, weren't useful from the viewpoint of clinicians all for the diagnosis of person tumors.
Read or Download Atlas of Exocrine Pancreatic Tumors: Morphology, Biology, and Diagnosis with an International Guide for Tumor Classification PDF
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Extra info for Atlas of Exocrine Pancreatic Tumors: Morphology, Biology, and Diagnosis with an International Guide for Tumor Classification
Note the abundance of collagen between the cysts. (H&E, X32). b High-power view of the large cyst depicted III a. Partial denudation of the epithelium, which is composed of uniform cells with dark nuclei. (H&E, X 210). c A small cyst filled with desquamated epithelium and hemosiderin-laden macrophages. Most of the cyst wall is denuded. (H&E, X21O) Immunohistochemistry Fig. 8. a,b. The same tumor as in Figs . 2and 3, a showing abundant cytoplasmic periodic acid Schiff (PAS)-positive granules, b which were completely digested by diastase 37 Serous Cystadenoma Fig.
Tonofilaments and microtubules are scattered in the cytoplasm. A few lipid droplets are present in normal acinar cells. Lipid droplets may be greatly increased in patients with diabetes mellitus, obesity, or alcohol abuse . Annulate lamellae, which are normal components of ova and Sertoli cells, are not found in normal acinar cells. However, they may be found in tumor cells showing acinar differentiation (such as acinar cell carcinoma and pancreatoblastoma) . unit, where intercalated ducts (ductules) are continuous with centroacinar cells.
The reported female to male ratio ranges up to 6: 1 [3, 11]. The macrocystic form occurred in three women and two men . Age Most cases occur in patients above 60 years of age (range: 34-88 years, with a mean of 68 years). The age of the 5 patients with macrocystic serous cystadenoma was between 46 and 67 . Etiology and Pathogenesis The etiology of serous cystadenoma is unknown. This tumor is sometimes associated with diabetes mellitus, von Hippel-Lindau syndrome, and extrapancreatic neoplasms.