Download Atypical Antipsychotics (Medical Psychiatry) by John C. Csernansky, John Lauriello PDF

By John C. Csernansky, John Lauriello

ISBN-10: 0824754123

ISBN-13: 9780824754129

Showcasing the most recent reports within the box, this reference unveils contemporary breakthroughs within the use of strange antipsychotics for the therapy of a number of sufferer populations-tracking advancements within the administration of sufferers with schizophrenia and affective psychotic problems, in addition to healing regimens for kids and teens.

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J Pharmacol Exp Ther 2001; 299(1):83– 89. 39. Roth BL, et al. Binding of typical and atypical antipsychotic agents to 5hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 1994; 268(3):1403–1410. Probing the "receptorome" unveils the receptor pharmacology 33 40. Kohen R, et al. Cloning, characterization, and chromosomal localization of a human 5- HT6 serotonin receptor. J Neurochem 1996; 66(1): 47–56. 41. Kroeze WK, Roth BL. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis.

This notion is based on the observation that Group II mGluR agonists attenuate the effects of hallucinogens on 5-HT2A-mediated actions (59,118). Studies with mGluR agonists in schizophrenia are ongoing. Atypical antipsychotics 28 III. CONCLUSIONS The main conclusion of this review is that multiple pharmacological mechanisms are likely to contribute to the actions of atypical antipsychotic drugs (Table 7). Thus, although a balanced antagonism of 5-HT2A serotonin and D2-dopamine receptors provides a reliable template to produce “atypical” antipsychotic drugs, other targeting strategies are also Table 7 Classification of Atypical Antipsychotic Drugs Based on Pharmacological Mechanism 5-HT2A/D2 D2/D3 D2 partial agonist 5-HT2A inverse agonists Drug Risperidone; ziprasidone; olanzapine; quetiapine; clozapine Amisulpride; remoxipride Aripiprazole M100907; SR46349B Extrapyramidal side effects Varies from absent (clozapine; quetiapine) to high (risperidone) Moderately low Low to absent None Weight gain liabilities Varies from low (ziprasidone) to high (clozapine, olanzapine) Moderately low Low None Low Low Low/none Anticholinergic/orthostasis Varies likely to be successful.

Adrenergic Receptors It has been known for many decades that antipsychotic drugs have varying affinities for adrenergic receptors, in particular, α1- and α2-adrenergic receptor subtypes (77–80). There are now at least nine distinct adrenergic receptors in three families: α1-, α2-, and βadrenergic; Table 4 lists the average affinities of atypical antipsychotic drugs at cloned human α1A-, α1B-, α2A-, α2B-, and α2C-adrenergic receptors, since antipsychotic drugs do not generally have appreciable affinities for β-adrenergic sites.

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