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ISBN-10: 0471324418

ISBN-13: 9780471324416

"A reference that are supposed to be within the own library of any biologist who makes use of the web for the research of DNA and protein series facts" --Science

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Additional info for Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Volume 39

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The DNA, RNA, or protein sequences are the items to be computed on and worked with. These are the valuable components of the primary databases. 20 THE GENBANK SEQUENCE DATABASE Those who compute, analyze, or simply work with DNA sequence records generally assume that they are dealing with primary information. In many cases, however, amino acid sequences are the result of some level of interpretation; they are rarely sequenced themselves, Thus great care is needed in the use and interpretation of results derived from these sequences.

This information is shown on the CDS feature. The CDS Feature As described in detail in Chapter 6 , the CDS is an instruction to the reader on how to join two sequences together, or on how to make an amino acid sequence from the indicated coordinates and the inferred genetic code. The GBFF view, being as DNA-centric as it is, maps all features through a DNA sequence coordinate system, not that of amino acid reference points, as in the following example from GenBank accession Y 11895 (contributed by a submission to EMBL).

1 LOCUS 10 20 AF010325 30 3291 bp 40 DNA 50 70 60 INV I 79 1 08- JUL-1997 The date on the LOCUS line is the date the record was last made public. In many cases this is also the date it was first made public. Another date contained in the record is the date the record was submitted (see below) to the database. It should be noted that none of these dates are legally binding on the promulgating organization. The databases make no claim that the dates are error-free; they are included as guides to users and should not be submitted in any arbitration dispute.

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