By John C. T. Church M.D., FRCS (auth.), Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, Christopher M.H. Kim, Kosta Y. Mumcuoglu (eds.)
Biotherapy is outlined because the use of residing organisms within the remedy and analysis of human and animal ailments. This quantity is an evocative exploration of the historical past, clinical foundation and useful use of the foremost biotherapy modalities. The authors supply researchers and practitioners attracted to this box, with state of the art fabric at the most modern key advances within the following fields of biotherapy: Maggot treatment, Hirudotherapy, Bee Venom remedy, Apitherapy, Ichthyotherapy, Helminth remedy, Phage remedy, Animal Assisted remedy, dogs Olfactory Detection. furthermore, the authors supply with their chapters an intensive bibliography that represents a cutting-edge survey of the literature. entire and present, this clean quantity of studies is a necessary source for pros who have to remain sooner than the sport within the intriguing box of biotherapy.
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Extra info for Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms
Armstrong et al. (2005) demonstrated the clinical relevance of this by establishing a case-controlled study of maggot therapy for lower extremity wounds in hospice patients: maggot therapy resulted in fewer clinical assessments of infection, less use of antibiotics, and fewer amputations. 3 Growth Stimulation William Baer observed that wounds debrided with maggots heal normally thereafter. But if maggot therapy is continued beyond the point of complete debridement, then the wounds heal even faster than expected (Baer 1931).
The leech has three rigid jaws arranged in a tri-radiated configuration. Sixty to 100 pyramidal, sharp teeth on each jaw are used to incise the skin leaving a characteristic Y-shaped bite (Fig. 2b). On the side of each tooth, close to the piercing tip, there is an opening through which saliva is injected into the skin (Orevi et al. 2000). After piercing the skin and injecting saliva, the leech starts blood-feeding, gradually releasing saliva chemicals, which are responsible for the therapeutic benefits of hirudotherapy.
For just as long, researchers have attempted to isolate the therapeutic molecules in hopes of being able to provide “maggot therapy” without the maggots. These efforts are valuable because they will yield a better understanding of the mechanisms of maggot therapy, as well as a better understanding of wound healing itself. Still, the efficacy of maggot therapy does not lie with a single molecule, nor even a whole family of molecules, but rather a family of molecules in the ideal relative concentrations, combined with the maggot’s anatomy and ambulatory behavior that bring these molecules into the recesses of the wound while the maggots physically debride the wound.